Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23778275 | 0.84 | OPRM1 (0.45) | OPRM1OPRL1OPRK1HTR1AHTR2A | |
| SCHEMBL23778328 | 0.80 | OPRM1 (0.43) | OPRM1OPRL1OPRK1HTR1AHTR2A | |
| SCHEMBL23778284 | 0.80 | OPRM1 (0.43) | OPRM1OPRL1OPRK1HTR1AHTR2A | |
| SCHEMBL20066170 | 0.79 | OPRM1 (0.58) | OPRM1OPRL1OPRK1HTR1AHTR2A | |
| SCHEMBL20073985 | 0.78 | OPRM1 (0.52) | OPRM1OPRL1OPRK1HTR1AHTR2A | |
| Trifluoroacetic Acid SCHEMBL23778426 | 0.77 | OPRM1 (0.49) | OPRM1OPRL1OPRK1HTR1AHTR2A | |
| SCHEMBL23778254 | 0.77 | OPRM1 (0.42) | OPRM1OPRL1OPRK1HTR1AHTR2A | |
| SCHEMBL20066072 | 0.77 | OPRM1 (0.44) | OPRM1OPRL1OPRK1HTR1ACALCRL | |
| SCHEMBL23778277 | 0.77 | OPRM1 (0.42) | OPRM1OPRL1OPRK1HTR1AHTR2A | |
| SCHEMBL29709409 | 0.77 | OPRM1 (0.44) | OPRM1OPRL1OPRK1HTR1ACALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526207-B1 | HETEROCYCLIC COMPOUNDS HAVING ACTIVITY AS MODULATORS OF MUSCARINIC M1 AND/OR M4 RECEPTORS IN THE TREATMENT OF CNS DISEASES AND PAINS. | HEPTARES THERAPEUTICS LTD (GB) | 2021-09-08 | — | — | EP | claimed |