Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23779129 | 0.88 | HRH4 (0.51) | HRH4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23779140 | 0.87 | GRM5 (0.33) | HRH4 | |
| SCHEMBL23779103 | 0.84 | HDAC6 (0.50) | HRH4HDAC6 | |
| SCHEMBL23779092 | 0.81 | SYK (0.42) | HRH4SYK | |
| SCHEMBL23779087 | 0.81 | HRH4 (0.41) | HRH4 | |
| SCHEMBL23779101 | 0.80 | POLB (0.51) | HRH4HDAC6 | |
| SCHEMBL23779078 | 0.80 | HRH4 (0.36) | HRH4 | |
| SCHEMBL23779079 | 0.80 | HDAC6 (0.48) | HRH4HDAC6 | |
| SCHEMBL23779131 | 0.80 | HRH4 (0.36) | HRH4 | |
| SCHEMBL23779113 | 0.80 | HRH4 (0.39) | HRH4DRD2DRD3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3873910-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2021-09-08 | — | — | EP | disclosed |