Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23780473 | 1.00 | HDAC1 (0.48) | HDAC1HDAC6HDAC4HDAC8JAK2 | |
| SCHEMBL23780471 | 0.91 | HDAC6 (0.49) | HDAC1HDAC6HDAC4HDAC8JAK2 | |
| SCHEMBL23780469 | 0.91 | HDAC6 (0.49) | HDAC1HDAC6HDAC4HDAC8JAK2 | |
| SCHEMBL23780434 | 0.88 | HDAC1 (0.48) | HDAC1HDAC6HDAC4HDAC8JAK2 | |
| SCHEMBL23780432 | 0.88 | HDAC1 (0.48) | HDAC1HDAC6HDAC4HDAC8JAK2 | |
| SCHEMBL23780417 | 0.85 | HDAC6 (0.56) | HDAC1HDAC6HDAC4HDAC8JAK2 | |
| SCHEMBL23780427 | 0.85 | SMN1; SMN2 (0.51) | HDAC1HDAC6HDAC4GPR55S1PR1 | |
| SCHEMBL23780418 | 0.85 | HDAC6 (0.56) | HDAC1HDAC6HDAC4HDAC8JAK2 | |
| SCHEMBL23780425 | 0.85 | SMN1; SMN2 (0.51) | HDAC1HDAC6HDAC4GPR55S1PR1 | |
| SCHEMBL23780433 | 0.84 | HDAC6 (0.70) | HDAC1HDAC6HDAC4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814343-B1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2023-01-11 | — | — | EP | claimed |
| EP-3814343-B1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2023-01-11 | — | — | EP | disclosed |
| US-20210276991-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210276991-A1 | CARDIAC SARCOMERE INHIBITORS | TNNI3, TNNT2, MYLK2 | HDAC1 203/4885HDAC6 233/4885HDAC4 771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.