Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 6/20 | 0.41 |
| ▸ | EHMT1 | Q9H9B1 | 5/20 | 0.41 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20581314 | 0.99 | ACHE (0.42) | ACHEBRD4BRD2BRD3EHMT2 | |
| SCHEMBL20580883 | 0.87 | EHMT2 (0.55) | EHMT2EHMT1SPIN1EGFRPLK4 | |
| SCHEMBL23784352 | 0.87 | EHMT2 (0.53) | ACHEBRD4BRD2BRD3EHMT2 | |
| Hydrochloric Acid SCHEMBL20580862 | 0.86 | EHMT2 (0.53) | ACHEBRD4BRD2BRD3EHMT2 | |
| Hydrochloric Acid SCHEMBL20581131 | 0.86 | EHMT2 (0.54) | EHMT2EHMT1SPIN1EGFRPLK4 | |
| SCHEMBL23784345 | 0.81 | EHMT2 (0.48) | ACHEBRD4BRD2BRD3EHMT2 | |
| Hydrochloric Acid SCHEMBL20581217 | 0.81 | EHMT2 (0.47) | ACHEBRD4BRD2BRD3EHMT2 | |
| SCHEMBL20581184 | 0.78 | EHMT2 (0.55) | EHMT2EHMT1SPIN1EGFRPLK4 | |
| SCHEMBL23784350 | 0.78 | ACHE (0.49) | ACHEBRD4BRD2BRD3MAPT | |
| Hydrochloric Acid SCHEMBL28371971 | 0.78 | ACHE (0.49) | ACHEBRD4BRD2BRD3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634962-B1 | AZAINDOLE COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2023-05-24 | — | — | EP | disclosed |
| US-20210371417-A1 | AZAINDOLE COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2021-12-02 | — | — | US | disclosed |
| US-11111243-B2 | Azaindole compounds as histone methyltransferase inhibitors | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11111243-B2 | Azaindole compounds as histone methyltransferase inhibitors | EHMT2, EHMT1, EZH2 | ACHE 1400/4885BRD4 601/4885BRD2 267/4885 |
| US-20210371417-A1 | AZAINDOLE COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS | EHMT2, EHMT1, EZH2 | ACHE 1400/4885BRD4 601/4885BRD2 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.