Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 9/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 16/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31361600 | 0.86 | PRMT5 (0.55) | METTL3PRMT5WDR77 | |
| SCHEMBL21683411 | 0.86 | PRMT5 (0.55) | METTL3PRMT5WDR77 | |
| SCHEMBL18572684 | 0.82 | PRMT5 (0.65) | METTL3PRMT5WDR77 | |
| SCHEMBL18572100 | 0.78 | PRMT5 (0.81) | METTL3PRMT5WDR77 | |
| SCHEMBL18572102 | 0.77 | PRMT5 (0.53) | METTL3PRMT5WDR77 | |
| SCHEMBL18572054 | 0.77 | PRMT5 (0.53) | METTL3PRMT5WDR77 | |
| SCHEMBL22002157 | 0.75 | PRMT5 (0.53) | METTL3PRMT5WDR77 | |
| SCHEMBL24380419 | 0.75 | PRMT5 (0.53) | METTL3PRMT5WDR77 | |
| SCHEMBL21683323 | 0.75 | PRMT5 (0.68) | METTL3PRMT5WDR77 | |
| SCHEMBL31361727 | 0.75 | PRMT5 (0.68) | METTL3PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210277009-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210277009-A1 | PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT6 | METTL3 192/4885PRMT5 1/4885WDR77 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.