Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 15/20 | 0.60 |
| ▸ | LTB4R2 | Q9NPC1 | 10/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6802277 | 0.87 | LTB4R (0.58) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9417803 | 0.85 | LTB4R (0.57) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9417903 | 0.84 | LTB4R (0.55) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL27200085 | 0.84 | HTT (0.70) | LTB4RLTB4R2ALDH1A1CYP3A4HPGD | |
| SCHEMBL23788297 | 0.84 | HTT (0.51) | LTB4RLTB4R2TSHRKMT2AHTT | |
| SCHEMBL9417807 | 0.83 | LTB4R (0.56) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9417912 | 0.83 | LTB4R (0.58) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL23778068 | 0.82 | HTT (0.50) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL23788577 | 0.82 | HTT (0.50) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL22714672 | 0.82 | HTT (0.50) | LTB4RLTB4R2THRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3720857-B1 | 2-OXO-5H-CHROMENO[4,3-B]PYRIDINES FOR USE IN THE TREATMENT OF HEPATITIS B | GALAPAGOS NV (BE) | 2021-09-08 | — | — | EP | disclosed |