Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23240854 | 0.87 | CHRM2 (0.50) | CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL23240853 | 0.87 | CHRM2 (0.50) | CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL11955100 | 0.87 | CHRM2 (0.50) | CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL12747259 | 0.85 | CHRM2 (0.48) | CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL12747265 | 0.85 | CHRM2 (0.48) | CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL12747269 | 0.85 | CHRM2 (0.48) | CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL23240885 | 0.79 | THRA (0.33) | CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL23788668 | 0.78 | CHRM2 (0.37) | CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL15503177 | 0.72 | CHRM2 (0.37) | CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL8077626 | 0.72 | CHRM2 (0.47) | CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11820778-B2 | 2-azaspiro[3.4]octane derivatives as M4 agonists | NOVARTIS AG (CH) | 2023-11-21 | — | — | US | disclosed |
| US-20220411435-A1 | 2-AZASPIRO[3,4]OCTANE DERIVATIVES AS M4 AGONISTS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2022-12-29 | — | — | US | disclosed |
| US-20210275522-A1 | PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | ASCENTAGE PHARMA SUZHOU CO LTD (CN) | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210275522-A1 | PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | CDK2, CDK5, CDK6 | CHRM2 4613/4885CHRM4 4873/4885CHRM5 4732/4885 |
| US-20220411435-A1 | 2-AZASPIRO[3,4]OCTANE DERIVATIVES AS M4 AGONISTS | CHRM2, CHRM1, CHRM3 | CHRM2 1/4885CHRM4 4/4885CHRM5 5/4885 |
| US-11820778-B2 | 2-azaspiro[3.4]octane derivatives as M4 agonists | CHRM2, CHRM1, CHRM3 | CHRM2 1/4885CHRM4 4/4885CHRM5 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.