Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23788556 | 0.90 | PPARG (0.31) | KMT2A | |
| SCHEMBL23788455 | 0.82 | PPARG (0.31) | KDM4EALDH1A1KMT2A | |
| SCHEMBL23788627 | 0.80 | TSHR (0.33) | KDM4EALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL23788552 | 0.80 | PPARG (0.31) | KMT2A | |
| SCHEMBL23788409 | 0.75 | HSP90AA1 (0.33) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL23788412 | 0.74 | REN (0.31) | — | |
| SCHEMBL23788408 | 0.73 | — | — | |
| SCHEMBL23788411 | 0.73 | REN (0.31) | — | |
| SCHEMBL23788534 | 0.73 | — | — | |
| SCHEMBL23788608 | 0.70 | MEN1 (0.35) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3720857-B1 | 2-OXO-5H-CHROMENO[4,3-B]PYRIDINES FOR USE IN THE TREATMENT OF HEPATITIS B | GALAPAGOS NV (BE) | 2021-09-08 | — | — | EP | disclosed |