Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 20/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17858935 | 0.94 | ESR1 (0.67) | ESR1CYP3A4KCNH2 | |
| SCHEMBL17858907 | 0.93 | ESR1 (0.66) | ESR1CYP3A4KCNH2 | |
| SCHEMBL21012130 | 0.92 | ESR1 (0.73) | ESR1 | |
| SCHEMBL23793738 | 0.92 | ESR1 (0.73) | ESR1 | |
| SCHEMBL22213732 | 0.90 | ESR1 (0.60) | ESR1CYP3A4KCNH2 | |
| SCHEMBL22881884 | 0.90 | ESR1 (0.62) | ESR1 | |
| SCHEMBL24027047 | 0.89 | ESR1 (0.59) | ESR1 | |
| SCHEMBL24027012 | 0.88 | ESR1 (0.60) | ESR1 | |
| SCHEMBL31280249 | 0.87 | ESR1 (0.57) | ESR1CYP3A4KCNH2 | |
| SCHEMBL17858901 | 0.87 | ESR1 (0.62) | ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091550-A1 | METHODS OF TREATING ESTROGEN RECEPTOR-ASSOCIATED DISEASES | OLEMA PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2021178846-A1 | METHODS OF TREATING ESTROGEN RECEPTOR-ASSOCIATED DISEASES | OLEMA PHARMACEUTICALS, INC. (US) | 2021-09-10 | — | — | WO | disclosed |