Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 19/20 | 0.54 |
| ▸ | SIK1 | P57059 | 1/20 | 0.43 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.43 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23794264 | 1.00 | HPGDS (0.54) | HPGDSSIK1SIK2SIK3 | |
| SCHEMBL19021516 | 0.89 | HPGDS (0.56) | HPGDS | |
| SCHEMBL19021455 | 0.88 | HPGDS (0.54) | HPGDS | |
| SCHEMBL18987514 | 0.87 | HPGDS (0.53) | HPGDS | |
| SCHEMBL19019768 | 0.87 | HPGDS (0.54) | HPGDS | |
| SCHEMBL18987443 | 0.87 | HPGDS (0.59) | HPGDS | |
| SCHEMBL18988091 | 0.87 | HPGDS (0.54) | HPGDS | |
| SCHEMBL18988002 | 0.87 | HPGDS (0.59) | HPGDS | |
| SCHEMBL19021274 | 0.87 | HPGDS (0.59) | HPGDS | |
| SCHEMBL18988090 | 0.87 | HPGDS (0.54) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390384-B1 | QUINOLINE-3-CARBOXAMIDES AS H-PGDS INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2021-09-15 | — | — | EP | claimed |