Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.66 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.66 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.47 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29841955 | 1.00 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL23795638 | 0.90 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL20550895 | 0.83 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL23795661 | 0.83 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL29842044 | 0.83 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL4918512 | 0.80 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL23795646 | 0.79 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11CSNK1E | |
| SCHEMBL29841886 | 0.79 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11CSNK1E | |
| SCHEMBL30022945 | 0.77 | TGFBR1 (0.60) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL20550929 | 0.77 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3877383-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF RESPIRATORY DISEASES | The University of Melbourne (AU) | 2021-09-15 | — | — | EP | disclosed |
| CN-113272298-A | Compounds and compositions for the treatment of respiratory diseases | 墨尔本大学 | 2021-08-17 | — | — | CN | disclosed |