Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.47 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 9/20 | 0.40 |
| ▸ | HTR2A | P28223 | 9/20 | 0.40 |
| ▸ | HTR7 | P34969 | 9/20 | 0.40 |
| ▸ | HTR6 | P50406 | 9/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23798012 | 0.86 | MAPK14 (0.45) | MAPK14 | |
| SCHEMBL23778419 | 0.85 | BACE1 (0.44) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL23798606 | 0.84 | OPRM1 (0.40) | OPRM1OPRK1OPRL1HTR1AHTR2A | |
| SCHEMBL23799157 | 0.84 | HRH4 (0.37) | OPRM1OPRK1OPRL1HTR7MAPK14 | |
| SCHEMBL23798696 | 0.83 | HRH4 (0.36) | OPRM1OPRK1OPRL1HTR1AHTR2A | |
| SCHEMBL29709346 | 0.82 | CHRM1 (0.45) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL20073883 | 0.82 | CHRM1 (0.45) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL29709353 | 0.82 | CHRM1 (0.45) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL20073879 | 0.82 | CHRM1 (0.45) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL23798681 | 0.81 | OPRM1 (0.47) | OPRM1OPRK1OPRL1BACE1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526207-B1 | HETEROCYCLIC COMPOUNDS HAVING ACTIVITY AS MODULATORS OF MUSCARINIC M1 AND/OR M4 RECEPTORS IN THE TREATMENT OF CNS DISEASES AND PAINS. | HEPTARES THERAPEUTICS LTD (GB) | 2021-09-08 | — | — | EP | disclosed |