Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 18/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 11/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117892 | 1.00 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL26688568 | 1.00 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL23798791 | 1.00 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL117891 | 1.00 | HSD11B1 (1.00) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| Water SCHEMBL15153123 | 0.99 | HSD11B1 (0.98) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| Water SCHEMBL23777526 | 0.99 | HSD11B1 (0.98) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| Water SCHEMBL15153126 | 0.99 | HSD11B1 (0.98) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL3218945 | 0.95 | HSD11B1 (0.90) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL3218954 | 0.95 | HSD11B1 (0.90) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL117742 | 0.94 | HSD11B1 (0.89) | HSD11B1CYP2C9CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3878446-A1 | HSD11B1 INHIBITORS FOR USE IN IMMUNOTHERAPY AND USES THEREOF | UNIVERSITE DE GENEVE (CH) | 2021-09-15 | — | — | EP | disclosed |