SCHEMBL23801154

SCHEMBL23801154

Cc1sc2c(c1C)C(c1ccc(-c3ccc(O)cc3F)cc1)=N[C@@H](CC(=O)O)c1nnc(C)n1-2

nearest known ligand 0.71

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 20/20 0.71
BRD2 P25440 4/20 0.62
BRD3 Q15059 2/20 0.60
DNER Q8NFT8 1/20 0.60
ADORA3 P0DMS8 1/20 0.58
TSPO P30536 1/20 0.58
BRDT Q58F21 3/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3211228 0.92 BRD4 (0.72) BRD4BRD2BRD3DNERADORA3
SCHEMBL23801064 0.92 BRD4 (0.73) BRD4BRD2BRD3DNERADORA3
SCHEMBL23321453 0.91 BRD4 (0.72) BRD4BRD2BRD3DNERADORA3
SCHEMBL23801161 0.90 BRD4 (0.76) BRD4BRD2BRD3DNERADORA3
SCHEMBL31548657 0.90 BRD4 (0.84) BRD4BRD2BRD3DNERADORA3
SCHEMBL23320790 0.90 BRD4 (0.68) BRD4BRD2BRD3DNERADORA3
SCHEMBL23321253 0.89 BRD4 (0.70) BRD4BRD2BRD3DNERADORA3
SCHEMBL23801110 0.89 BRD4 (0.82) BRD4BRD2BRD3DNERADORA3
SCHEMBL23801163 0.89 BRD4 (0.69) BRD4BRD2BRD3DNERADORA3
SCHEMBL23321117 0.88 BRD4 (0.66) BRD4BRD2BRD3DNERADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11542273-B2 Amide compound having bet proteolysis-inducing action and medicinal application thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2023-01-03 US disclosed
US-20210284654-A1 AMIDE COMPOUND HAVING BET PROTEOLYSIS-INDUCING ACTION AND MEDICINAL APPLICATION THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2021-09-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11542273-B2 Amide compound having bet proteolysis-inducing action and medicinal application thereof BET1, BRD4, PHKB BRD4 2/4885BRD2 16/4885BRD3 7/4885
US-20210284654-A1 AMIDE COMPOUND HAVING BET PROTEOLYSIS-INDUCING ACTION AND MEDICINAL APPLICATION THEREOF BET1, BRD4, PHKB BRD4 2/4885BRD2 16/4885BRD3 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.