PHKB

Phosphorylase kinase beta subunit · Q93100 · PHKB on Sugi Atlas →

281 patent compounds predicted against PHKB, 250 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL8321621)	1.00	3/20
SCHEMBL8323028	1.00	3/20
Hydrochloric Acid (SCHEMBL8323337)	1.00	3/20
Hydrochloric Acid (SCHEMBL8323340)	1.00	3/20
Hydrochloric Acid (SCHEMBL8323341)	1.00	3/20
SCHEMBL8325893	1.00	3/20
SCHEMBL8325899	1.00	3/20
SCHEMBL8325901	1.00	3/20
SCHEMBL30569343	1.00	3/20
SCHEMBL8325755	0.84	3/20
SCHEMBL8325756	0.84	3/20
SCHEMBL8325761	0.84	3/20
SCHEMBL8328590	0.84	3/20
Hydrochloric Acid (SCHEMBL8325486)	0.83	3/20
Hydrochloric Acid (SCHEMBL8325487)	0.83	3/20
Hydrochloric Acid (SCHEMBL8325673)	0.83	3/20
Hydrochloric Acid (SCHEMBL8325674)	0.83	3/20
Hydrochloric Acid (SCHEMBL8322489)	0.81	3/20
Hydrochloric Acid (SCHEMBL8326455)	0.81	3/20
Hydrochloric Acid (SCHEMBL8326458)	0.81	3/20

Clinical trials — most relevant to PHKB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL	PHASE1/PHASE2	RECRUITING
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients	PHASE2	COMPLETED
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma	PHASE1/PHASE2	COMPLETED
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer	PHASE2	COMPLETED
Avelumab in Relapsed or Refractory Extranodal Natural Killer/T-cell Lymphoma[AVENT STUDY]	PHASE2	UNKNOWN
Vorinostat in Children	PHASE1/PHASE2	COMPLETED
Biological Effects of Quercetin in COPD Phase II	PHASE2	UNKNOWN
A First-in-Human Study of JAB-8263 in Adult Patients With Advanced Solid Tumors	PHASE1	COMPLETED
ZEN003694 Combined With Niraparib in Patients With Metastatic or Recurrent Solid Tumors	PHASE1	WITHDRAWN
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
Dexanabinol in Patients With Brain Cancer	PHASE1	COMPLETED
Ricolinostat, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Unresectable or Metastatic Cholangiocarcinoma	PHASE1	WITHDRAWN
Effectiveness of Light for Enhancement of Cognition by Transcranial Repeated Application (ELECTRA)	EARLY_PHASE1	COMPLETED
Novel Molecular Targets and Innovative Therapeutic Perspective in Medulloblastoma	EARLY_PHASE1	RECRUITING
p38 Mitogen-Activated Protein Kinase (MAPK) and Steroid Insensitivity in Asthma	nan	COMPLETED
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma	nan	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
IKBKB Gene Polymorphism (Single Nucleotide Polymorphism) (SNP) in Psoriatic and Psoriatic Arthritis Patients	nan	COMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics	nan	UNKNOWN
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients	nan	COMPLETED
A Pilot Study of Biomarkers for Spinal Muscular Atrophy	nan	COMPLETED
Novel Biomarkers in Inflammatory Bowel Disease	nan	COMPLETED
Evaluation of Innovative Combinatorial stratégies of Anti-latency and Anti-immune Activation Drugs Targeting HIV Reservoir	nan	WITHDRAWN
Studying Tissue Samples From Patients With Stage II Colon Cancer Treated on Clinical Trial CLB-9581	nan	COMPLETED
Identification of Novel Targetable Kinases in SR-a GvHD	nan	COMPLETED
Study of Proteins in Head and Neck Cancer Cells	nan	COMPLETED
The Effect of Raising Ketones Directly With MCT Oil on Inflammation in Healthy Young Adults	nan	COMPLETED
Maximizing Mechanisms of Muscle Hypertrophy to Combat Sarcopenia in Older Adults	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PHKB binder may also engage these)

Protein	Name	Similarity
Q9VLS1	—	1.000	Q9VLS1 →
Q7TSH2	—	1.000	Q7TSH2 →
Q8BWJ3	—	1.000	Q8BWJ3 →
P12798	—	1.000	P12798 →
PHKA1	Phosphorylase b kinase regulatory subunit alp	1.000	landscape →
Q64649	—	1.000	Q64649 →
PHKA2	Phosphorylase b kinase regulatory subunit alpha, liver isoform	1.000	landscape →
P46018	—	1.000	P46018 →
P22047	—	1.000	P22047 →
Q6CLU6	—	1.000	Q6CLU6 →
Q8BD31	—	0.999	Q8BD31 →
P03541	—	0.999	P03541 →
P19239	—	0.999	P19239 →
Q00159	—	0.999	Q00159 →
Q94218	—	0.999	Q94218 →
P07400	—	0.998	P07400 →
Q23652	—	0.998	Q23652 →
P07973	—	0.998	P07973 →
O46431	—	0.998	O46431 →
P0CA08	—	0.998	P0CA08 →
P31924	—	0.998	P31924 →
Q91PB2	—	0.998	Q91PB2 →
Q67171	—	0.998	Q67171 →
Q93CE8	—	0.998	Q93CE8 →
Q9V3D2	—	0.997	Q9V3D2 →
Q90038	—	0.997	Q90038 →
P0DJR6	—	0.997	P0DJR6 →
Q8BDE5	—	0.997	Q8BDE5 →
Q85431	—	0.997	Q85431 →
Q7XNX6	—	0.997	Q7XNX6 →