Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22447940 | 0.93 | HPGD (0.62) | HPGDTSHRALDH1A1EPHX2RECQL | |
| SCHEMBL14577252 | 0.85 | HPGD (0.53) | HPGDTSHRALDH1A1EPHX2RECQL | |
| SCHEMBL26700591 | 0.84 | HPGD (0.50) | HPGDALDH1A1EPHX2RECQLKMT2A | |
| SCHEMBL26700589 | 0.84 | HPGD (0.50) | HPGDALDH1A1EPHX2RECQLKMT2A | |
| SCHEMBL101437 | 0.83 | HPGD (0.56) | HPGDTSHREPHX2RECQLHTT | |
| SCHEMBL20668574 | 0.82 | TSHR (0.55) | HPGDTSHRALDH1A1RECQLHTT | |
| SCHEMBL23729802 | 0.82 | HPGD (0.51) | HPGDALDH1A1EPHX2RECQLSMN1; SMN2 | |
| SCHEMBL23729800 | 0.81 | HPGD (0.48) | HPGDEPHX2RECQLSMN1; SMN2CYP2D6 | |
| SCHEMBL19477902 | 0.81 | TSHR (0.50) | HPGDTSHRALDH1A1RECQLHTT | |
| SCHEMBL8468908 | 0.81 | GAA (0.47) | HPGDTSHRALDH1A1RECQLHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021178725-A1 | COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY | VERVE THERAPEUTICS, INC. (US) | 2021-09-10 | — | — | WO | disclosed |