Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 14/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26581653 | 0.89 | MCL1 (0.48) | MCL1GRIN2B | |
| SCHEMBL23809241 | 0.88 | MCL1 (0.46) | MCL1GRIN2BHDAC1HDAC6GRIN1 | |
| SCHEMBL23799579 | 0.88 | MCL1 (0.45) | MCL1GRIN2BHDAC1HDAC6KDM4C | |
| SCHEMBL23809054 | 0.83 | GRIN2B (0.43) | GRIN2BGRIN1 | |
| SCHEMBL23809510 | 0.82 | GRIN2B (0.39) | MCL1GRIN2BGRIN1 | |
| SCHEMBL20604902 | 0.81 | GRIN2B (0.42) | MCL1GRIN2BHDAC1HDAC6GRIN1 | |
| SCHEMBL26581654 | 0.78 | MCL1 (0.49) | MCL1GRIN2B | |
| SCHEMBL23800108 | 0.76 | MCL1 (0.47) | MCL1GRIN2BHDAC1HDAC6GRIN1 | |
| SCHEMBL26581651 | 0.70 | GRIN2B (0.53) | GRIN2B | |
| SCHEMBL20605093 | 0.70 | MCL1 (0.42) | MCL1GRIN2BHDAC1HDAC6GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | MCL1 1/4885GRIN2B 3904/4885HDAC1 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.