Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 20/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809510 | 0.85 | GRIN2B (0.39) | GRIN2BGRIN1 | |
| SCHEMBL26581651 | 0.85 | GRIN2B (0.53) | GRIN2B | |
| SCHEMBL20604981 | 0.84 | GRIN2B (0.44) | GRIN2B | |
| SCHEMBL23809057 | 0.83 | MCL1 (0.44) | GRIN2BGRIN1 | |
| SCHEMBL23809241 | 0.78 | MCL1 (0.46) | GRIN2BGRIN1 | |
| SCHEMBL23809421 | 0.76 | DYRK1A (0.40) | — | |
| SCHEMBL23799893 | 0.75 | GRIN2B (0.51) | GRIN2BGRIN1 | |
| SCHEMBL23809334 | 0.74 | KDR (0.37) | — | |
| SCHEMBL23809246 | 0.74 | MEN1 (0.43) | — | |
| SCHEMBL23809336 | 0.73 | ICMT (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | GRIN2B 3904/4885GRIN1 2916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.