Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.35 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809116 | 0.82 | HDAC1 (0.40) | MEN1KMT2AACE2EIF4A3CYP2C9 | |
| SCHEMBL12665424 | 0.76 | LMNA (0.45) | MEN1KMT2AIKBKETBK1EIF4A3 | |
| SCHEMBL29715820 | 0.74 | MEN1 (0.49) | MEN1KMT2ASCN9ASCN5A | |
| SCHEMBL1554607 | 0.73 | ACE2 (0.51) | ACE2MTNR1AMTNR1BKDM4ESLC22A12 | |
| SCHEMBL16939392 | 0.72 | EIF4A3 (0.50) | MEN1KMT2AIKBKETBK1ACE2 | |
| SCHEMBL18911990 | 0.71 | MEN1 (0.46) | MEN1KMT2ANOTUM | |
| SCHEMBL9381103 | 0.71 | LMNA (0.50) | MEN1KMT2ACYP2C9KDM4E | |
| SCHEMBL23809242 | 0.71 | KMT2A (0.35) | MEN1KMT2AFABP4MTNR1AMTNR1B | |
| SCHEMBL22822628 | 0.70 | NR4A2 (0.49) | SCN9ASCN5ACYP3A4CYP2C8CYP2C9 | |
| SCHEMBL31160199 | 0.70 | MEN1 (0.45) | MEN1KMT2ASCN9ASCN5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | MEN1 3549/4885KMT2A 824/4885IKBKE 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.