Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | CMA1 | P23946 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12607920 | 0.88 | MTNR1A (0.50) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL12565589 | 0.84 | HDAC6 (0.44) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL1554607 | 0.84 | ACE2 (0.51) | MTNR1AMTNR1B | |
| SCHEMBL1554429 | 0.83 | MTNR1A (0.49) | MTNR1AMTNR1B | |
| SCHEMBL23809275 | 0.83 | HASPIN (0.53) | CMA1 | |
| SCHEMBL1553090 | 0.82 | MTNR1A (0.42) | MTNR1AMTNR1BSCN9ACMA1 | |
| SCHEMBL23809393 | 0.82 | KDM4E (0.46) | MTNR1AMTNR1B | |
| SCHEMBL23809408 | 0.81 | GAA (0.47) | CMA1 | |
| SCHEMBL23809488 | 0.81 | KDM4E (0.49) | — | |
| SCHEMBL15039164 | 0.81 | SCN9A (0.49) | HDAC6HDAC1HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | HDAC6 275/4885HDAC1 358/4885HDAC8 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.