Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 5/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.41 |
| ▸ | ACE | P12821 | 4/20 | 0.41 |
| ▸ | CPA1 | P15085 | 3/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18067342 | 0.87 | KMT2A (0.55) | TDP1PTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL27095768 | 0.85 | TDP1 (0.57) | TDP1PTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL458048 | 0.85 | TDP1 (0.57) | TDP1PTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL25356249 | 0.85 | TDP1 (0.57) | TDP1PTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL25357735 | 0.82 | PLA2G10 (0.51) | TDP1PTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL25356783 | 0.82 | PLA2G10 (0.51) | TDP1PTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL25356787 | 0.82 | PLA2G10 (0.51) | TDP1PTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL161943 | 0.80 | FOLH1 (0.60) | MEN1KMT2AL3MBTL1MMEACE2 | |
| SCHEMBL22444653 | 0.80 | PPARG (0.47) | L3MBTL1MMEACE2ACECPA1 | |
| SCHEMBL160418 | 0.80 | FOLH1 (0.60) | MEN1KMT2AL3MBTL1MMEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170821-B1 | COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES | AMBRX INC (US) | 2021-09-15 | — | — | EP | disclosed |