Sugi Predict

Sugi Predict / Compounds / SCHEMBL458048

SCHEMBL458048

SCHEMBL458048

CN[C@@H](Cc1ccc(C(=O)O)cc1)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.57
▸ KMT2A Q03164 4/20 0.55
▸ L3MBTL1 Q9Y468 3/20 0.55
▸ MEN1 O00255 2/20 0.55
▸ ALDH1A1 P00352 1/20 0.50
▸ FOLH1 Q04609 5/20 0.49
▸ ANPEP P15144 1/20 0.49
▸ ENPEP Q07075 1/20 0.49
▸ ACACB O00763 1/20 0.47
▸ PTPN1 P18031 1/20 0.47
▸ SRD5A2 P31213 1/20 0.46
▸ MME P08473 1/20 0.44
▸ ACE P12821 1/20 0.44
▸ CPA1 P15085 1/20 0.44
▸ ACE2 Q9BYF1 1/20 0.44
▸ HTT P42858 1/20 0.44
▸ ADRB1 P08588 1/20 0.43
▸ ADRB3 P13945 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27095768 1.00 TDP1 (0.57) TDP1KMT2AL3MBTL1MEN1ALDH1A1
SCHEMBL25356249 1.00 TDP1 (0.57) TDP1KMT2AL3MBTL1MEN1ALDH1A1
SCHEMBL18067342 0.88 KMT2A (0.55) TDP1KMT2AL3MBTL1MEN1ALDH1A1
SCHEMBL14898375 0.88 KMT2A (0.50) TDP1KMT2AL3MBTL1MEN1ALDH1A1
SCHEMBL25357735 0.86 PLA2G10 (0.51) TDP1KMT2AL3MBTL1MEN1FOLH1
SCHEMBL25356787 0.86 PLA2G10 (0.51) TDP1KMT2AL3MBTL1MEN1FOLH1
SCHEMBL25356783 0.86 PLA2G10 (0.51) TDP1KMT2AL3MBTL1MEN1FOLH1
SCHEMBL15898500 0.85 GAA (0.48) TDP1KMT2AL3MBTL1MEN1ALDH1A1
SCHEMBL23809602 0.85 CES2 (0.44) TDP1KMT2AL3MBTL1MEN1FOLH1
SCHEMBL161943 0.84 FOLH1 (0.60) KMT2AL3MBTL1MEN1FOLH1MME

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025100520-A1 PEPTIDE, PEPTIDE COMPLEX, PHARMACEUTICAL COMPOSITION, COMPOSITION FOR CELL CULTURE, AND COMPOSITION FOR MEDICAL USE, DIAGNOSTIC USE, OR RESEARCH USE ペプチドリーム株式会社 2025-05-15 — — WO claimed
US-20230257343-A1 NOVEL AMINO ACID DERIVATIVES PEPTIDREAM INC (JP) 2023-08-17 — — US claimed
EP-4667483-A1 HUMAN TRANSFERRIN RECEPTOR-BINDING PEPTIDE JCR Pharmaceuticals Co., Ltd. (JP) 2025-12-24 — — EP disclosed
WO-2025100520-A1 PEPTIDE, PEPTIDE COMPLEX, PHARMACEUTICAL COMPOSITION, COMPOSITION FOR CELL CULTURE, AND COMPOSITION FOR MEDICAL USE, DIAGNOSTIC USE, OR RESEARCH USE ペプチドリーム株式会社 2025-05-15 — — WO disclosed
WO-2025070720-A1 PEPTIDE ペプチドリーム株式会社 2025-04-03 — — WO disclosed
WO-2025070731-A1 PEPTIDEPEPTIDE ペプチドリーム株式会社 2025-04-03 — — WO disclosed
WO-2024172166-A1 HUMAN TRANSFERRIN RECEPTOR-BINDING PEPTIDE ＪＣＲファーマ株式会社 2024-08-22 — — WO disclosed
US-20230257343-A1 NOVEL AMINO ACID DERIVATIVES PEPTIDREAM INC (JP) 2023-08-17 — — US disclosed
US-20230257343-A1 NOVEL AMINO ACID DERIVATIVES PEPTIDREAM INC (JP) 2023-08-17 — — US disclosed
US-20230257343-A1 NOVEL AMINO ACID DERIVATIVES PEPTIDREAM INC (JP) 2023-08-17 — — US disclosed
US-10407482-B2 Amino acid substituted molecules ALLOZYNE, INC. (US) 2019-09-10 — — US disclosed
US-7632492-B2 Use of host cells in forming modified target molecules, including therapeutic molecules having non-natural amino acids in their sequence; biosynthesis; drug conjugates ALLOZYNE, INC. (US) 2009-12-15 — — US disclosed
EP-2018437-A2 NON-NATURAL AMINO ACID SUBSTITUTED POLYPEPTIDES Allozyne, Inc. (US) 2009-01-28 — — EP disclosed
US-20080214439-A1 AMINO ACID SUBSTITUTED MOLECULES ALLOZYNE, INC. (US) 2008-09-04 — — US disclosed
US-20080200641-A1 AMINO ACID SUBSTITUTED MOLECULES ALLOZYNE, INC. (US) 2008-08-21 — — US disclosed
US-20080125347-A1 AMINO ACID SUBSTITUTED MOLECULES ALLOZYNE, INC. (US) 2008-05-29 — — US disclosed
US-20080096819-A1 Amino acid substituted molecules ALLOZYNE, INC. (US) 2008-04-24 — — US disclosed
US-20080051317-A1 Polypeptides comprising unnatural amino acids, methods for their production and uses therefor CODON DEVICES, INC. 2008-02-28 — — US disclosed
WO-2007130453-A2 NON-NATURAL AMINO ACID SUBSTITUTED POLYPEPTIDES ALLOZYNE, INC. (US) 2007-11-15 — — WO disclosed
WO-2007075438-A2 POLYPEPTIDES COMPRISING UNNATURAL AMINO ACIDS, METHODS FOR THEIR PRODUCTION AND USES THEREFOR CODON DEVICES, INC. (US) 2007-07-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10407482-B2 Amino acid substituted molecules BCAT2, DNPEP, PTMS TDP1 4484/4885KMT2A 839/4885L3MBTL1 3197/4885
US-20080096819-A1 Amino acid substituted molecules BCAT2, DNPEP, PTMS TDP1 4484/4885KMT2A 839/4885L3MBTL1 3197/4885
US-20080214439-A1 AMINO ACID SUBSTITUTED MOLECULES BCAT2, DNPEP, PTMS TDP1 4484/4885KMT2A 839/4885L3MBTL1 3197/4885
US-20080200641-A1 AMINO ACID SUBSTITUTED MOLECULES BCAT2, DNPEP, PTMS TDP1 4484/4885KMT2A 839/4885L3MBTL1 3197/4885
US-20230257343-A1 NOVEL AMINO ACID DERIVATIVES DNPEP, BCAT1, ANPEP TDP1 3630/4885KMT2A 3083/4885L3MBTL1 1836/4885
US-20080125347-A1 AMINO ACID SUBSTITUTED MOLECULES BCAT2, DNPEP, PTMS TDP1 4484/4885KMT2A 839/4885L3MBTL1 3197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.