Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.36 |
| ▸ | FDPS | P14324 | 4/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19021461 | 1.00 | ACE2 (0.44) | ACE2OPRM1CA1SPHK1LMNA | |
| SCHEMBL18514502 | 0.93 | ACE2 (0.36) | ACE2OPRM1CA1SPHK1TP53 | |
| SCHEMBL5683923 | 0.81 | ACE2 (0.47) | ACE2OPRM1CA1SPHK1LMNA | |
| SCHEMBL19466238 | 0.80 | ACE2 (0.52) | ACE2OPRM1SPHK1LMNAGPR84 | |
| SCHEMBL28277613 | 0.79 | ACE2 (0.50) | ACE2OPRM1SPHK1LMNAGPR84 | |
| SCHEMBL28154759 | 0.79 | ACE2 (0.50) | ACE2OPRM1SPHK1LMNAGPR84 | |
| SCHEMBL22986050 | 0.79 | LMNA (0.50) | OPRM1CA1SPHK1LMNAGPR84 | |
| SCHEMBL6181574 | 0.79 | ACE2 (0.50) | ACE2OPRM1SPHK1LMNAGPR84 | |
| SCHEMBL28277594 | 0.79 | ACE2 (0.50) | ACE2OPRM1SPHK1LMNAGPR84 | |
| SCHEMBL23139229 | 0.78 | ACE2 (0.42) | ACE2OPRM1SPHK1LMNAGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390384-B1 | QUINOLINE-3-CARBOXAMIDES AS H-PGDS INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2021-09-15 | — | — | EP | disclosed |