Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 6/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | STAMBP | O95630 | 1/20 | 0.35 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18988140 | 0.88 | MGAM (0.44) | HPGDSGRIN2BPSMD14PDGFRBPDGFRA | |
| Hydrochloric Acid SCHEMBL18987700 | 0.86 | MGAM (0.43) | HPGDSGRIN2BPSMD14PDGFRBPDGFRA | |
| SCHEMBL19021109 | 0.85 | HPGDS (0.45) | HPGDSGRIN2BPSMD14STAMBPCOPS5 | |
| SCHEMBL19020880 | 0.83 | HPGDS (0.50) | HPGDSGRIN2BPSMD14STAMBPCOPS5 | |
| SCHEMBL19020876 | 0.83 | HPGDS (0.46) | HPGDSPSMD14STAMBPCOPS5PDGFRB | |
| SCHEMBL7081027 | 0.81 | HPGDS (0.53) | HPGDSPSMD14STAMBPCOPS5PDGFRB | |
| SCHEMBL18987834 | 0.78 | HPGDS (0.48) | HPGDS | |
| SCHEMBL18987833 | 0.78 | HPGDS (0.48) | HPGDS | |
| SCHEMBL19021507 | 0.78 | HPGDS (0.48) | HPGDS | |
| SCHEMBL3873425 | 0.78 | HPGDS (0.58) | HPGDSPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390384-B1 | QUINOLINE-3-CARBOXAMIDES AS H-PGDS INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2021-09-15 | — | — | EP | disclosed |