Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 7/20 | 0.48 |
| ▸ | HSPA9 | P38646 | 4/20 | 0.48 |
| ▸ | HSPA2 | P54652 | 3/20 | 0.48 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | RRM1 | P23921 | 1/20 | 0.34 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23818888 | 0.94 | HSPA5 (0.53) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23818767 | 0.80 | HSPA5 (0.53) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23804603 | 0.69 | HSPA5 (0.76) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23804600 | 0.69 | HSPA5 (0.76) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23818463 | 0.69 | HSPA5 (0.72) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23804620 | 0.69 | HSPA5 (1.00) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23804624 | 0.69 | HSPA5 (1.00) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23818768 | 0.66 | HSPA5 (0.53) | HSPA5HSPA9HSPA2HSPA8 | |
| SCHEMBL21224485 | 0.64 | HTT (0.74) | HSPA5HSPA9HTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL21224486 | 0.64 | HTT (0.74) | HSPA5HSPA9HTTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021183942-A1 | INHIBITORS OF HSP70 PROTEINS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-09-16 | — | — | WO | disclosed |