Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | OAT | P04181 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11919497 | 0.83 | BTK (0.40) | BTKAPLNRPOLBLMNAGRM2 | |
| SCHEMBL16699710 | 0.83 | OAT (0.35) | OATAPLNRCYP2C19GABRR1 | |
| SCHEMBL16708925 | 0.83 | OAT (0.35) | OATAPLNRCYP2C19GABRR1 | |
| SCHEMBL16699712 | 0.83 | OAT (0.35) | OATAPLNRCYP2C19GABRR1 | |
| SCHEMBL301155 | 0.70 | — | — | |
| SCHEMBL12582055 | 0.70 | — | — | |
| SCHEMBL12449971 | 0.70 | — | — | |
| SCHEMBL16434120 | 0.69 | HTT (0.33) | OAT | |
| SCHEMBL8970350 | 0.69 | BTK (0.44) | BTKAPLNRPOLBLMNAGRM2 | |
| SCHEMBL16276337 | 0.69 | BTK (0.44) | BTKAPLNRPOLBLMNAGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021180774-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2021-09-16 | — | — | WO | disclosed |