OAT

Ornithine aminotransferase, mitochondrial · P04181 · OAT on Sugi Atlas →

219 patent compounds predicted against OAT, 162 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29317634	0.33	2/20
SCHEMBL29979297	0.33	2/20
Gabaculine (SCHEMBL6237522)	1.00	1/20
SCHEMBL12689554	1.00	1/20
Gabaculine (SCHEMBL22691967)	1.00	1/20
Gabaculine (SCHEMBL23622815)	1.00	1/20
Hydrochloric Acid (SCHEMBL22440735)	0.97	1/20
Gabaculine (SCHEMBL23142324)	0.96	1/20
SCHEMBL22459885	0.76	1/20
SCHEMBL22459920	0.76	1/20
SCHEMBL22459893	0.69	1/20
SCHEMBL22460134	0.69	1/20
SCHEMBL22459897	0.67	1/20
Cpp-115 Free Base (SCHEMBL2407298)	0.66	1/20
Cpp-115 Free Base (SCHEMBL2408171)	0.66	1/20
Cpp-115 Free Base (SCHEMBL2411394)	0.66	1/20
Cpp-115 Free Base (SCHEMBL12258069)	0.66	1/20
Cpp-115 Free Base (SCHEMBL21404893)	0.66	1/20
Cpp-115 Free Base (SCHEMBL14687433)	0.64	1/20
Cpp-115 Free Base (SCHEMBL15142226)	0.64	1/20

Clinical trials — most relevant to OAT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
L-ornithine L-aspartate in Overt Hepatic Encephalopathy	PHASE4	COMPLETED
Efficacy of L-Ornithine-L-Aspartate in Cirrhotics With Hepatic Encephalopathy	PHASE3	COMPLETED
Betaine and Peroxisome Biogenesis Disorders	PHASE3	COMPLETED
Obeticholic Acid Among Chronic HBV Patients with Hepatic Steatosis : Clinical and Portal Doppler Outcomes	PHASE3	NOT_YET_RECRUITING
A Research Study Investigating Mim8 in Adults and Adolescents With Haemophilia A With or Without Inhibitors	PHASE3	COMPLETED
A Phase I/II Open-label Safety and Efficacy Study of LNP.UCD.ABE in Patients With Urea Cycle Disorders.	PHASE1/PHASE2	NOT_YET_RECRUITING
Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure	PHASE2	UNKNOWN
The KHENERGY Study	PHASE2	COMPLETED
Effect of Tulsi (Ocimum Sanctum) on Biochemical Parameters in Young Overweight and Obese Subjects	PHASE2	COMPLETED
Halting Ornithine Transcarbamylase Deficiency With Recombinant AAV in ChildrEn	PHASE1/PHASE2	RECRUITING
Human Heterologous Liver Cells for Infusion in Children With Urea Cycle Disorders	PHASE2	COMPLETED
Trial of Oxaloacetate in Alzheimer's Disease (TOAD)	PHASE1	COMPLETED
Study of Treatment and Metabolism in Patients With Urea Cycle Disorders	PHASE1	UNKNOWN
Brain Imaging in Patients With Chronic Liver Disease and Functional Impairment.	nan	COMPLETED
Longitudinal Study of Urea Cycle Disorders	nan	RECRUITING
Study in Healthy Subjects, Patients With Urea Cycle Disorders (UCD) and Carriers of UCD Mutations to Evaluate Urea Cycle Function	nan	COMPLETED
Predicts Mortality by AST/ALT Ration in Patients with Sepsis and Septic Shock During ICU Admissin	nan	NOT_YET_RECRUITING
Supplementation With Altha-aminoacids and Systemiec Inflammatory Response in Long-distance Runners.	nan	UNKNOWN
PCORI Urea Cycle Disorder Study	nan	COMPLETED
Longitudinal Study of Mitochondrial Hepatopathies	nan	SUSPENDED
Pilot Study: Urea Cycle Disorders Practice Patterns and Outcomes Assessment	nan	COMPLETED
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
The Effect of Arginine and Citrulline Supplementation on Endothelial Dysfunction in Mitochondrial Diseases	nan	COMPLETED
Multi-omics Study in Citrin Deficiency	nan	ACTIVE_NOT_RECRUITING
Effects of Parenteral L-carnitine Supplementation in Premature Neonates	nan	COMPLETED
Relationship Between Fatigue and Mitochondrial Damage in Patients With HIV/AIDS	nan	COMPLETED
Liver Metabolic Functions in Patients With Citrin Deficiency and Healthy Subjects	nan	ACTIVE_NOT_RECRUITING
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases	nan	COMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Metabolism of Ornithine Phenylacetate	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a OAT binder may also engage these)

Protein	Name	Similarity
P29758	—	1.000	P29758 →
P04182	—	0.999	P04182 →
Q3ZCF5	—	0.998	Q3ZCF5 →
Q9VW26	—	0.987	Q9VW26 →
P49724	—	0.984	P49724 →
Q18040	—	0.955	Q18040 →
P61922	—	0.953	P61922 →
Q07346	—	0.951	Q07346 →
P50554	—	0.946	P50554 →
CTH	Cystathionine gamma-lyase	0.946	landscape →
Q9LSH2	—	0.944	Q9LSH2 →
Q5RDE7	—	0.943	Q5RDE7 →
Q9ZPS3	—	0.943	Q9ZPS3 →
Q99P39	—	0.942	Q99P39 →
Q9Z1J3	—	0.942	Q9Z1J3 →
Q42472	—	0.941	Q42472 →
Q9ZPS4	—	0.941	Q9ZPS4 →
Q42521	—	0.941	Q42521 →
P00504	—	0.940	P00504 →
Q5R691	—	0.940	Q5R691 →
Q6B855	—	0.939	Q6B855 →
P40142	—	0.939	P40142 →
Q60HG7	—	0.939	Q60HG7 →
Q6P8M1	—	0.939	Q6P8M1 →
P13221	—	0.938	P13221 →
P50137	—	0.938	P50137 →
P54767	—	0.938	P54767 →
Q9Y697	—	0.937	Q9Y697 →
Q4R5L1	—	0.937	Q4R5L1 →
P27818	—	0.937	P27818 →