SCHEMBL23822902

SCHEMBL23822902

CC(C)(C)CCCNC(=O)c1cc(-c2ccccc2)on1

nearest known ligand 0.73

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 5/20 0.73
FAAH O00519 3/20 0.67
HDAC6 Q9UBN7 2/20 0.65
HDAC3 O15379 1/20 0.65
HDAC1 Q13547 1/20 0.65
HDAC2 Q92769 1/20 0.65
HDAC10 Q969S8 1/20 0.65
HDAC8 Q9BY41 1/20 0.65
HTT P42858 3/20 0.64
LMNA P02545 4/20 0.60
KMT2A Q03164 4/20 0.60
RAB9A P51151 6/20 0.59
SMN1; SMN2 Q16637 6/20 0.59
NPC1 O15118 5/20 0.59
TP53 P04637 2/20 0.58
POLB P06746 1/20 0.56
MAPK1 P28482 1/20 0.56
HPGD P15428 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23822913 0.90 HIF1A (0.70) HIF1AFAAHHDAC6HDAC3HDAC1
SCHEMBL23823000 0.89 HIF1A (0.72) HIF1AFAAHHDAC6HDAC3HDAC1
SCHEMBL17079551 0.85 HIF1A (0.76) HIF1AFAAHHDAC6HDAC3HDAC1
SCHEMBL17540248 0.85 HIF1A (0.76) HIF1AFAAHHDAC6HDAC3HDAC1
SCHEMBL17511041 0.84 HIF1A (0.80) HIF1AFAAHHDAC6HDAC3HDAC1
SCHEMBL17540249 0.83 HIF1A (0.67) HIF1AFAAHHDAC6HDAC3HDAC1
SCHEMBL23822891 0.83 HIF1A (0.97) HIF1AFAAHHDAC6HDAC3HDAC1
SCHEMBL19440767 0.83 HIF1A (0.78) HIF1AFAAHHDAC6HDAC3HDAC1
SCHEMBL17079565 0.83 HIF1A (0.78) HIF1AFAAHHDAC6HDAC3HDAC1
SCHEMBL12349834 0.83 TP53 (0.78) HIF1AFAAHHDAC6HDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021183937-A1 SUBSTITUTED ISOXAZOLES AS SELECTIVE NAV1.7 INHIBITORS FOR PAIN TREATMENT AND METHOD OF PAIN TREATMENT BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-09-16 WO disclosed