Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.62 |
| ▸ | FAAH | O00519 | 3/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SCD | O00767 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30644710 | 0.95 | HIF1A (0.62) | HIF1AHDAC6HDAC1HDAC3HDAC10 | |
| SCHEMBL17079555 | 0.85 | HIF1A (0.61) | HIF1AHDAC6HDAC1HDAC3HDAC10 | |
| SCHEMBL17079180 | 0.85 | HDAC6 (0.58) | HIF1AHDAC6HDAC1HDAC3HDAC10 | |
| SCHEMBL23822902 | 0.83 | HIF1A (0.73) | HIF1AHDAC6HDAC1HDAC3HDAC10 | |
| SCHEMBL17540248 | 0.83 | HIF1A (0.76) | HIF1AHDAC6HDAC1HDAC3HDAC10 | |
| SCHEMBL17079551 | 0.83 | HIF1A (0.76) | HIF1AHDAC6HDAC1HDAC3HDAC10 | |
| SCHEMBL17511041 | 0.83 | HIF1A (0.80) | HIF1AHDAC6HDAC1HDAC3HDAC10 | |
| SCHEMBL19442568 | 0.82 | HIF1A (0.64) | HIF1AHDAC6HDAC1HDAC3HDAC10 | |
| SCHEMBL19440767 | 0.82 | HIF1A (0.78) | HIF1AHDAC6HDAC1HDAC3HDAC10 | |
| SCHEMBL23822913 | 0.81 | HIF1A (0.70) | HIF1AHDAC6HDAC1HDAC3HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783510-B2 | Small molecule mediated transcriptional induction of E-cadherin | VANDERBILT UNIVERSITY (US) | 2017-10-10 | — | — | US | disclosed |
| US-9783510-B2 | Small molecule mediated transcriptional induction of E-cadherin | VANDERBILT UNIVERSITY (US) | 2017-10-10 | — | — | US | disclosed |
| US-9505729-B2 | Isoxazole analogs as mediators of transcriptional induction of E-cadherin | VANDERBILT UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| US-9505729-B2 | Isoxazole analogs as mediators of transcriptional induction of E-cadherin | VANDERBILT UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| US-20160052896-A1 | ISOXAZOLE ANALOGS AS MEDIATORS OF TRANSCRIPTIONAL INDUCTION OF E-CADHERIN | VANDERBILT UNIVERSITY | 2016-02-25 | — | — | US | disclosed |
| US-20160052896-A1 | ISOXAZOLE ANALOGS AS MEDIATORS OF TRANSCRIPTIONAL INDUCTION OF E-CADHERIN | VANDERBILT UNIVERSITY | 2016-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052896-A1 | ISOXAZOLE ANALOGS AS MEDIATORS OF TRANSCRIPTIONAL INDUCTION OF E-CADHERIN | CDH1, VIM, EPCAM | HIF1A 388/4885HDAC6 132/4885HDAC1 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.