Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 13/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.43 |
| ▸ | CDK1 | P06493 | 8/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.43 |
| ▸ | CDK2 | P24941 | 7/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645308 | 0.87 | AURKA (0.41) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL12582690 | 0.87 | PDPK1 (0.43) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL12304231 | 0.84 | AURKA (0.53) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL8300923 | 0.84 | ACKR3 (0.46) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL8302956 | 0.83 | AURKA (0.49) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL8305065 | 0.82 | AURKA (0.45) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL13446057 | 0.82 | AURKA (0.42) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL8305800 | 0.81 | LMNA (0.49) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL8300921 | 0.81 | AURKA (0.43) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL8299872 | 0.81 | AURKB (0.53) | AURKAAURKBCDK1CCNB1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110224203-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224203-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | CDK1, CCNI, CDK2 | AURKA 4/4885AURKB 6/4885CDK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.