SCHEMBL23831792

SCHEMBL23831792

O=C(Nc1cc(F)cc(NCCO)c1)Nc1cc(Br)ccc1CO

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.42
NPC1 O15118 4/20 0.42
RAB9A P51151 4/20 0.42
ALDH1A1 P00352 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
KMT2A Q03164 7/20 0.39
MEN1 O00255 6/20 0.39
MAPT P10636 6/20 0.39
HTT P42858 4/20 0.39
MAPK1 P28482 1/20 0.39
HSD17B10 Q99714 1/20 0.39
GRIK1 P39086 2/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
TRPV1 Q8NER1 1/20 0.36
CASP3 P42574 2/20 0.36
SENP7 Q9BQF6 2/20 0.36
SENP6 Q9GZR1 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30105003 1.00 LMNA (0.42) LMNANPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL23831791 0.93 GRIK1 (0.42) LMNANPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL30105260 0.93 GRIK1 (0.42) LMNANPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL30104952 0.91 LMNA (0.43) LMNANPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL23831989 0.91 LMNA (0.43) LMNANPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL30105302 0.90 LMNA (0.48) LMNANPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL27077612 0.90 LMNA (0.48) LMNANPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL23831978 0.89 KMT2A (0.46) LMNANPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL30105176 0.89 KMT2A (0.46) LMNANPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL23831831 0.89 MAPT (0.42) LMNANPC1RAB9ASMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121415-B1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES UNIV PALACKEHO (CZ) 2024-02-07 EP disclosed
EP-4121415-A1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES Univerzita Palackého v Olomouci (CZ) 2023-01-25 EP disclosed
WO-2021185391-A1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2021-09-23 WO disclosed