Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.41 |
| ▸ | CTSD | P07339 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.39 |
| ▸ | CTSE | P14091 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371186 | 0.81 | BACE1 (0.47) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL1999573 | 0.72 | CYP11B1 (0.43) | BACE1CTSDKCNH2 | |
| SCHEMBL15509971 | 0.70 | BACE1 (0.73) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL2526504 | 0.70 | BACE1 (0.73) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL2517564 | 0.67 | BACE1 (0.50) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL2383153 | 0.67 | BACE1 (0.43) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL1995683 | 0.63 | BACE1 (0.65) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL3279074 | 0.63 | BACE1 (0.68) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL3274085 | 0.63 | BACE1 (0.65) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL2010383 | 0.63 | BACE1 (0.72) | BACE1CTSDKCNH2CTSEBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547685-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |