Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.60 |
| ▸ | GPR39 | O43194 | 5/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.47 |
| ▸ | MERTK | Q12866 | 2/20 | 0.47 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23837629 | 0.94 | HIF1A (0.62) | TRPM8HIF1AGPR39AXLFLT3 | |
| SCHEMBL1442185 | 0.81 | TRPM8 (1.00) | TRPM8HIF1AHTTKMT2ASMN1; SMN2 | |
| SCHEMBL1442021 | 0.76 | TRPM8 (0.89) | TRPM8HIF1AGPR39HTTKMT2A | |
| SCHEMBL1443136 | 0.73 | HIF1A (0.55) | TRPM8HIF1AGPR39HTTKMT2A | |
| SCHEMBL13728183 | 0.71 | KDM4E (0.55) | TRPM8HIF1AHTTKMT2ASMN1; SMN2 | |
| SCHEMBL23837660 | 0.69 | SMN1; SMN2 (0.52) | TRPM8HIF1AHTTKMT2ASMN1; SMN2 | |
| SCHEMBL1699181 | 0.68 | TRPM8 (0.67) | TRPM8HIF1AGPR39AXLFLT3 | |
| SCHEMBL1699208 | 0.68 | TRPM8 (0.67) | TRPM8GPR39AXLFLT3TYRO3 | |
| SCHEMBL30532224 | 0.68 | TRPM8 (0.67) | TRPM8HIF1AGPR39AXLFLT3 | |
| SCHEMBL30532225 | 0.68 | TRPM8 (0.67) | TRPM8GPR39AXLFLT3TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473486-B2 | PYRIMIDINES AS HEPCIDINE ANTAGONISTS | VIFOR INT AG (CH) | 2021-09-22 | — | — | EP | disclosed |