Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 4/20 | 0.64 |
| ▸ | CDK9 | P50750 | 4/20 | 0.64 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.64 |
| ▸ | CCNK | O75909 | 2/20 | 0.64 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.64 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.64 |
| ▸ | CCNH | P51946 | 2/20 | 0.64 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.64 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.64 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.44 |
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20421822 | 0.89 | CDK9 (0.80) | CDK7CDK9CSNK1A1CCNKCDK12 | |
| SCHEMBL18480107 | 0.89 | CDK9 (0.80) | CDK7CDK9CSNK1A1CCNKCDK12 | |
| SCHEMBL21648732 | 0.88 | CDK9 (0.81) | CDK7CDK9CSNK1A1CCNKCDK12 | |
| SCHEMBL21648785 | 0.88 | CDK7 (0.81) | CDK7CDK9CSNK1A1CCNKCDK12 | |
| SCHEMBL23666447 | 0.86 | CDK7 (0.48) | CDK7CDK9CSNK1A1CCNKCDK12 | |
| SCHEMBL22858143 | 0.85 | CDK9 (0.79) | CDK7CDK9CSNK1A1CCNKCDK12 | |
| SCHEMBL22858342 | 0.83 | CDK7 (0.80) | CDK7CDK9CSNK1A1CCNKCDK12 | |
| SCHEMBL22858144 | 0.81 | CDK7 (0.80) | CDK7CDK9CSNK1A1CCNKCDK12 | |
| SCHEMBL23666446 | 0.81 | CDK7 (0.53) | CDK7CDK9CSNK1A1CCNKCDK12 | |
| SCHEMBL18480113 | 0.80 | PIK3C3 (0.61) | CDK7CDK9CSNK1A1CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331877-B1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL) | 2021-09-22 | — | — | EP | disclosed |