Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.30 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25477755 | 0.87 | PRMT6 (0.37) | PRMT6KDM4EKMT2ATDP1HRH1 | |
| SCHEMBL24572503 | 0.87 | PRMT6 (0.37) | PRMT6KDM4EKMT2ATDP1HRH1 | |
| SCHEMBL26280128 | 0.87 | PRMT6 (0.37) | PRMT6KDM4EKMT2ATDP1HRH1 | |
| SCHEMBL25882001 | 0.85 | PRMT6 (0.38) | PRMT6KDM4EKMT2ATDP1HRH1 | |
| SCHEMBL24508520 | 0.85 | PRMT6 (0.38) | PRMT6KDM4EKMT2ATDP1HRH1 | |
| SCHEMBL21107910 | 0.83 | PRMT6 (0.35) | PRMT6KDM4EKMT2ATDP1HRH1 | |
| SCHEMBL23696344 | 0.83 | PRMT6 (0.35) | PRMT6KDM4EKMT2ATDP1HRH1 | |
| SCHEMBL23696220 | 0.82 | PRMT6 (0.36) | PRMT6KDM4EKMT2ATDP1HRH1 | |
| SCHEMBL23602775 | 0.81 | PRMT6 (0.35) | PRMT6KDM4EKMT2ATDP1HRH1 | |
| SCHEMBL25705791 | 0.81 | KDM4E (0.36) | PRMT6KDM4EKMT2ATDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188948-A1 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |