Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 17/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | WEE1 | P30291 | 1/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | NEK2 | P51955 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18426821 | 0.82 | ITK (1.00) | ITKCHEK1PLK4AURKACCNB2 | |
| SCHEMBL20775477 | 0.80 | ITK (0.62) | ITKCYP19A1 | |
| SCHEMBL18426832 | 0.78 | ITK (0.75) | ITKCHEK1PLK4AURKACCNB2 | |
| SCHEMBL18426830 | 0.77 | ITK (0.73) | ITKCHEK1CYP19A1 | |
| SCHEMBL5247261 | 0.77 | GSK3B (0.49) | ITKABL1SRCKDRCYP19A1 | |
| SCHEMBL18494204 | 0.76 | PIM1 (0.69) | ITK | |
| SCHEMBL1270888 | 0.75 | PIM1 (0.54) | CDK2TTKFLT3AURKB | |
| SCHEMBL29470244 | 0.75 | ITK (1.00) | ITKCHEK1 | |
| SCHEMBL145584 | 0.75 | ITK (1.00) | ITKCHEK1 | |
| SCHEMBL18426858 | 0.75 | ITK (0.75) | ITKCHEK1PLK4AURKACCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115650985-A | Heterocyclic compounds as RET kinase inhibitors | 癌症研究科技有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-109195972-B | Heterocyclic compounds as RET kinase inhibitors | 癌症研究科技有限公司 | 2022-10-28 | — | — | CN | disclosed |
| US-9629843-B2 | MTOR modulators and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-04-25 | — | — | US | disclosed |
| US-20160000789-A1 | MTOR MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-01-07 | — | — | US | disclosed |
| US-20110224223-A1 | MTOR Modulators and Uses Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) | 2011-09-15 | — | — | US | disclosed |
| WO-2010006072-A2 | MTOR MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160000789-A1 | MTOR MODULATORS AND USES THEREOF | MTOR, RPTOR, RICTOR | ITK 2193/4885CHEK1 719/4885PLK4 833/4885 |
| US-20110224223-A1 | MTOR Modulators and Uses Thereof | MTOR, RPTOR, RICTOR | ITK 2193/4885CHEK1 719/4885PLK4 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.