Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 6/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876288 | 0.78 | ITK (0.60) | GSK3BRETKDRSRCABL1 | |
| SCHEMBL2384271 | 0.77 | ITK (0.70) | KDRSRCABL1ITKCYP19A1 | |
| SCHEMBL2927510 | 0.76 | PRKDC (0.56) | GSK3BRETKDRSRCABL1 | |
| SCHEMBL5249228 | 0.75 | GSK3B (0.48) | GSK3BRETKDRSRCABL1 | |
| SCHEMBL28221040 | 0.74 | RAB9A (0.53) | GSK3BRETKDRSRCABL1 | |
| SCHEMBL5179280 | 0.73 | ITK (0.61) | GSK3BRETKDRITKCYP19A1 | |
| SCHEMBL1901060 | 0.73 | GSK3B (0.56) | GSK3BRETKDRSRCABL1 | |
| SCHEMBL4125890 | 0.72 | ITK (0.54) | GSK3BRETKDRITKCYP19A1 | |
| SCHEMBL2396563 | 0.72 | METAP2 (0.57) | GSK3BRETKDRSRCABL1 | |
| SCHEMBL21945267 | 0.71 | ITK (0.49) | GSK3BRETKDRSRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848506-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | Attenuon, LLC (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089298-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | ATTENUON, LLC (US) | 2006-08-24 | — | — | WO | disclosed |