Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754053 | 0.81 | SMPD3 (0.33) | SMPD3PDE10A | |
| SCHEMBL23754051 | 0.81 | SMPD3 (0.33) | SMPD3PDE10A | |
| SCHEMBL23754003 | 0.78 | SMPD3 (0.36) | SMPD3PDE10A | |
| SCHEMBL31357751 | 0.78 | SMPD3 (0.36) | SMPD3PDE10A | |
| SCHEMBL23768950 | 0.72 | SMPD3 (0.39) | SMPD3PDE10A | |
| SCHEMBL23843150 | 0.70 | KLKB1 (0.35) | SMPD3PDE10A | |
| SCHEMBL23769616 | 0.69 | SMPD3 (0.36) | SMPD3PDE10A | |
| SCHEMBL23769391 | 0.69 | SMPD3 (0.34) | SMPD3PDE10A | |
| SCHEMBL23754018 | 0.69 | SMPD3 (0.34) | SMPD3PDE10A | |
| SCHEMBL29906555 | 0.69 | SMPD3 (0.34) | SMPD3PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210292301-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210292301-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KLKB1, KLK5, KLK1 | SMPD3 1629/4885PDE10A 3529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.