Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 19/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25366533 | 0.87 | ACSS2 (1.00) | ACSS2 | |
| SCHEMBL23843571 | 0.82 | ACSS2 (0.90) | ACSS2 | |
| SCHEMBL25367667 | 0.80 | ACSS2 (0.86) | ACSS2 | |
| SCHEMBL26046229 | 0.76 | ACSS2 (0.81) | ACSS2 | |
| SCHEMBL26046194 | 0.75 | ACSS2 (0.78) | ACSS2 | |
| SCHEMBL23832298 | 0.73 | ACSS2 (0.80) | ACSS2 | |
| SCHEMBL25367721 | 0.72 | ACSS2 (0.71) | ACSS2 | |
| SCHEMBL25367341 | 0.72 | ACSS2 (0.75) | ACSS2 | |
| SCHEMBL25367983 | 0.72 | ACSS2 (0.75) | ACSS2 | |
| SCHEMBL25366663 | 0.72 | ACSS2 (1.00) | ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021185789-A1 | CONDENSED PYRIDINE DERIVASTIVES SUBSTITUED BY AMIDE FUNCTIONS AS ACSS2 INHIBITORS | MERCK PATENT GMBH (DE) | 2021-09-23 | — | — | WO | disclosed |