2-Naphthylacetic Acid

2-Naphthylacetic Acid

SCHEMBL238445

O=C(O)Cc1ccc2ccccc2c1

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 2/20 0.71
AKR1B1 P15121 2/20 0.67
PTGS1 P23219 2/20 0.62
CYP1A2 P05177 2/20 0.62
AKR1C3 P42330 1/20 0.62
AKR1C2 P52895 1/20 0.62
LMNA P02545 2/20 0.55
GAA P10253 2/20 0.55
TSHR P16473 2/20 0.55
ABCC4 O15439 1/20 0.55
HTT P42858 1/20 0.55
ALOX5 P09917 1/20 0.54
PPARG P37231 1/20 0.54
KDM4E B2RXH2 1/20 0.53
RGS12 O14924 1/20 0.53
POLB P06746 1/20 0.53
MAPT P10636 1/20 0.53
HPGD P15428 1/20 0.53
NFKB1 P19838 1/20 0.53
APEX1 P27695 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Naphthylacetic Acid SCHEMBL30493868 1.00 NR1H4 (0.71) NR1H4AKR1B1PTGS1CYP1A2AKR1C3
2-Naphthylacetic Acid SCHEMBL28641469 1.00 NR1H4 (0.71) NR1H4AKR1B1PTGS1CYP1A2AKR1C3
2-Naphthylacetic Acid SCHEMBL29366514 1.00 NR1H4 (0.71) NR1H4AKR1B1PTGS1CYP1A2AKR1C3
2-Naphthylacetic Acid SCHEMBL10453180 0.98 NR1H4 (0.69) NR1H4AKR1B1PTGS1CYP1A2AKR1C3
2-Naphthylacetic Acid SCHEMBL11045683 0.98 NR1H4 (0.69) NR1H4AKR1B1PTGS1CYP1A2AKR1C3
2-Naphthylacetic Acid SCHEMBL11437704 0.98 NR1H4 (0.69) NR1H4AKR1B1PTGS1CYP1A2AKR1C3
2-Naphthylacetic Acid SCHEMBL7861322 0.96 NR1H4 (0.67) NR1H4AKR1B1PTGS1CYP1A2AKR1C3
2-Naphthylacetic Acid SCHEMBL29180271 0.96 NR1H4 (0.67) NR1H4AKR1B1PTGS1CYP1A2AKR1C3
2-Naphthylacetic Acid SCHEMBL11102091 0.96 NR1H4 (0.67) NR1H4AKR1B1PTGS1CYP1A2AKR1C3
2-Naphthylacetic Acid SCHEMBL23302248 0.94 NR1H4 (0.65) NR1H4AKR1B1PTGS1CYP1A2AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2384 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP claimed
US-12473465-B2 Ultraviolet radiation-cured pressure sensitive adhesives from plant oils or animal fats OREGON STATE UNIVERSITY (US) 2025-11-18 US claimed
CN-119959172-A Preparation method of hydrazine probe for detecting wastewater 郑州大学 2025-05-09 CN claimed
US-12291598-B2 Pressure sensitive adhesives made from UV curing of plant oil-based polyesters OREGON STATE UNIVERSITY (US) 2025-05-06 US claimed
CN-119841891-A Supermolecule dual-specificity self-assembled polypeptide for promoting endothelial cell repair, and preparation method, application and medicine thereof 南开国际先进研究院(深圳福田) 2025-04-18 CN claimed
CN-119541658-A Bionic antibacterial peptide, pharmaceutical composition, application of pharmaceutical composition in preparation of antibacterial drugs and design method of bionic antibacterial peptide 西湖大学 2025-02-28 CN claimed
CN-119504945-A Preparation and application of PKM2 enzyme response polypeptide hydrogel capable of simultaneously delivering PTX and GDC0919 南京医科大学 2025-02-25 CN claimed
CN-119331052-A Polypeptide derivative, nanofiber and application of polypeptide derivative and nanofiber in preparation of product for repairing tooth saphenous fissure 天津市口腔医院 2025-01-21 CN claimed
CN-119302319-A Safe and efficient eggplant flower and fruit retention compound and preparation method thereof 赣州市蔬菜质量标准中心 2025-01-14 CN claimed
US-12187664-B2 High purity 2-naphthylacetonitrile and method for producing same API CORPORATION (JP) 2025-01-07 US claimed
EP-0672162-A1 ENHANCED PRODUCTION OF TAXOL AND TAXANES BY CELL CULTURES OF $i(TAXUS) SPECIES PHYTON CATALYTIC, INC. (US) 1995-09-20 EP claimed
WO-1993017121-A1 ENHANCED PRODUCTION OF TAXOL AND TAXANES BY CELL CULTURES OF TAXUS SPECIES PHYTON CATALYTIC, INC. (US) 1993-09-02 WO claimed
EP-0265220-B1 METHOD FOR PRODUCING 2,6-DIACETOXYNAPHTHALENE HOECHST CELANESE CORPORATION (US) 1993-01-07 EP claimed
EP-0299973-B1 ANTHELMINTIC ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1992-06-17 EP claimed
WO-1991016920-A1 LIPID PRODRUGS OF SALICYLATE AND NONSTEROIDAL ANTI-INFLAMMATORY DRUGS VICAL, INC. (US) 1991-11-14 WO claimed
US-5006433-A Printing plate precursors for electrophotographic plate-making purposes FUJI PHOTO FILM CO., LTD. (JP) 1991-04-09 US claimed
EP-0299973-A1 ANTHELMINTIC ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS. UPJOHN CO (US) 1989-01-25 EP claimed
WO-1987006133-A1 ANTHELMINTIC ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1987-10-22 WO claimed
US-4362712-A Carboxylated naphthalene formaldehyde condensation polymers as dental plaque barriers JOHNSON & JOHNSON PRODUCTS, INC. (US) 1982-12-07 US claimed
US-4217730-A PLANT GROWTH HORMONES WEYERHAEUSER COMPANY (US) 1980-08-19 US claimed