Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2270553 | 0.83 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9AMAPTNPC1CA12 | |
| SCHEMBL7930570 | 0.83 | HDAC1 (0.48) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13814572 | 0.83 | GABRP (0.42) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL31052440 | 0.82 | PTPN1 (0.65) | SMN1; SMN2RAB9AMAPTNPC1MAPK1 | |
| SCHEMBL2232356 | 0.82 | MAPT (0.54) | SMN1; SMN2MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL8792557 | 0.81 | HSD17B10 (0.76) | SMN1; SMN2RAB9AMAPTNPC1HSD17B10 | |
| SCHEMBL19151154 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9AMAPTNPC1HSD17B10 | |
| SCHEMBL2081651 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AMAPTNPC1HSD17B10 | |
| SCHEMBL29403604 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AMAPTNPC1HSD17B10 | |
| SCHEMBL27262674 | 0.80 | POLB (0.53) | SMN1; SMN2RAB9AMAPTNPC1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188938-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE | AKEBIA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |