Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 4/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12948207 | 0.82 | KDM4E (0.42) | PKMKDM4EGABRPGABRDGABRA1 | |
| SCHEMBL9643724 | 0.82 | KDM4E (0.57) | PKMKDM4EGABRPGABRDGABRA1 | |
| SCHEMBL20139181 | 0.81 | KDM4E (0.33) | PKMKDM4E | |
| SCHEMBL9644296 | 0.81 | KDM4E (0.41) | PKMKDM4EKDRFLT1 | |
| Hydrochloric Acid SCHEMBL9644303 | 0.81 | KDM4E (0.55) | PKMKDM4EGABRPGABRDGABRA1 | |
| SCHEMBL5528025 | 0.78 | KMT2A (0.46) | PKMKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL859758 | 0.77 | HSD17B10 (0.42) | PKMKDM4EALDH1A1GAAHPGD | |
| SCHEMBL27727664 | 0.74 | PLA2G10 (0.46) | KDM4ELIMK1KDRALDH1A1HPGD | |
| SCHEMBL25767003 | 0.74 | ALDH1A1 (0.42) | PKMKDM4EKDRALDH1A1POLB | |
| SCHEMBL1667399 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188880-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |