⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30055213 | 0.76 | — | — | |
| SCHEMBL23832873 | 0.76 | — | — | |
| SCHEMBL26504187 | 0.75 | HCRTR1 (0.31) | — | |
| SCHEMBL31371154 | 0.74 | AKR1C3 (0.31) | — | |
| SCHEMBL23846910 | 0.72 | EPAS1 (0.40) | — | |
| SCHEMBL26182993 | 0.72 | — | — | |
| SCHEMBL31284561 | 0.72 | — | — | |
| SCHEMBL9280511 | 0.69 | DRD2 (0.37) | — | |
| SCHEMBL31371181 | 0.69 | — | — | |
| SCHEMBL31371088 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188769-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. (US) | 2021-09-23 | — | — | WO | disclosed |