Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.67 |
| ▸ | SRC | P12931 | 12/20 | 0.67 |
| ▸ | KDR | P35968 | 6/20 | 0.67 |
| ▸ | JAK2 | O60674 | 2/20 | 0.67 |
| ▸ | PLK4 | O00444 | 2/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.67 |
| ▸ | INSR | P06213 | 2/20 | 0.67 |
| ▸ | FYN | P06241 | 2/20 | 0.67 |
| ▸ | RET | P07949 | 2/20 | 0.67 |
| ▸ | ROS1 | P08922 | 2/20 | 0.67 |
| ▸ | FER | P16591 | 2/20 | 0.67 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.67 |
| ▸ | MARK3 | P27448 | 2/20 | 0.67 |
| ▸ | AXL | P30530 | 2/20 | 0.67 |
| ▸ | FLT4 | P35916 | 2/20 | 0.67 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.67 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.67 |
| ▸ | BLK | P51451 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL760441 | 1.00 | LCK (0.67) | LCKSRCKDRJAK2PLK4 | |
| SCHEMBL2960034 | 1.00 | LCK (0.67) | LCKSRCKDRJAK2PLK4 | |
| SCHEMBL760440 | 1.00 | LCK (0.67) | LCKSRCKDRJAK2PLK4 | |
| SCHEMBL31612025 | 0.93 | LCK (0.64) | LCKSRCKDRJAK2PLK4 | |
| SCHEMBL5812789 | 0.93 | LCK (0.64) | LCKSRCKDRJAK2PLK4 | |
| SCHEMBL4825086 | 0.90 | LCK (0.70) | LCKSRCKDRJAK2PLK4 | |
| SCHEMBL4828169 | 0.88 | LCK (0.61) | LCKSRCKDRJAK2PLK4 | |
| SCHEMBL4828163 | 0.88 | LCK (0.61) | LCKSRCKDRJAK2PLK4 | |
| SCHEMBL24096480 | 0.87 | JAK2 (0.86) | LCKSRCKDRJAK2PLK4 | |
| SCHEMBL29999054 | 0.87 | JAK2 (0.86) | LCKSRCKDRJAK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188417-A1 | COMPOUNDS FOR TREATING OR INHIBITING RECURRENCE OF ACUTE MYELOID LEUKEMIA | FLASH THERAPEUTICS, LLC (US) | 2021-09-23 | — | — | WO | disclosed |
| US-RE48175-E1 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-08-25 | — | — | US | disclosed |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-04-05 | — | — | US | disclosed |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-04-05 | — | — | US | disclosed |
| US-9758522-B2 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-9758522-B2 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-20150274738-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | Dana-Farber Cancer, Institute, Inc. (US) | 2015-10-01 | — | — | US | disclosed |
| US-20150274738-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | Dana-Farber Cancer, Institute, Inc. (US) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274738-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | MYC, TP53, MDM2 | LCK 401/4885SRC 322/4885KDR 1084/4885 |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | MYC, TP53, MDM2 | LCK 401/4885SRC 322/4885KDR 1084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.