Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.61 |
| ▸ | SRC | P12931 | 12/20 | 0.61 |
| ▸ | TEK | Q02763 | 11/20 | 0.61 |
| ▸ | KDR | P35968 | 6/20 | 0.61 |
| ▸ | BTK | Q06187 | 3/20 | 0.61 |
| ▸ | EGFR | P00533 | 8/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 8/20 | 0.52 |
| ▸ | IGF1R | P08069 | 7/20 | 0.52 |
| ▸ | ERBB3 | P21860 | 7/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 2/20 | 0.50 |
| ▸ | FYN | P06241 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | ROS1 | P08922 | 2/20 | 0.50 |
| ▸ | FER | P16591 | 2/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828163 | 1.00 | LCK (0.61) | LCKSRCTEKKDRBTK | |
| SCHEMBL23873623 | 0.92 | NUDT14 (0.54) | LCKSRCTEKKDRBTK | |
| SCHEMBL10261914 | 0.89 | NUDT14 (0.58) | LCKSRCTEKKDRBTK | |
| SCHEMBL24096479 | 0.88 | SRC (0.61) | LCKSRCKDRBTKEGFR | |
| SCHEMBL760440 | 0.88 | LCK (0.67) | LCKSRCTEKKDRBTK | |
| SCHEMBL23847532 | 0.88 | LCK (0.67) | LCKSRCTEKKDRBTK | |
| SCHEMBL2960034 | 0.88 | LCK (0.67) | LCKSRCTEKKDRBTK | |
| SCHEMBL760441 | 0.88 | LCK (0.67) | LCKSRCTEKKDRBTK | |
| SCHEMBL5822885 | 0.83 | LCK (0.77) | LCKSRCTEKKDRBTK | |
| SCHEMBL4818337 | 0.83 | LCK (0.77) | LCKSRCTEKKDRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332497-B2 | As inhibitors of protein kinases | ABBOTT GMBH & CO KG (DE) | 2008-02-19 | — | — | US | disclosed |
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| US-20040006083-A1 | Pyrazolopyrimidines as therapeutic agents | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2004-01-08 | — | — | US | disclosed |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006083-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, UGT1A1, ABCB1 | LCK 1534/4885SRC 2167/4885TEK 1218/4885 |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, CYP2D6, UGT1A1 | LCK 1011/4885SRC 1834/4885TEK 1657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.