Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.47 |
| ▸ | MTOR | P42345 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.44 |
| ▸ | TAF1 | P21675 | 3/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23848912 | 0.96 | ATR (0.51) | ATRMTORKCNH2PIK3CAATRIP | |
| SCHEMBL23848913 | 0.95 | ATR (0.48) | ATRMTORKCNH2PIK3CAATRIP | |
| SCHEMBL23848916 | 0.87 | ATR (0.54) | ATRMTORKCNH2PIK3CAATRIP | |
| SCHEMBL23848905 | 0.83 | ATR (0.58) | ATRMTORKCNH2PIK3CAATRIP | |
| SCHEMBL23848949 | 0.83 | ATR (0.50) | ATRMTORKCNH2PIK3CAATRIP | |
| SCHEMBL23848914 | 0.81 | ATR (0.54) | ATRMTORKCNH2PIK3CAATRIP | |
| SCHEMBL23848886 | 0.80 | ATR (0.51) | ATRMTORKCNH2PIK3CAATRIP | |
| SCHEMBL23848909 | 0.78 | PIK3CA (0.51) | ATRMTORPIK3CAATRIPATM | |
| SCHEMBL4207261 | 0.78 | ATR (0.49) | ATRMTORKCNH2PIK3CAATRIP | |
| SCHEMBL4198871 | 0.76 | ATR (0.49) | ATRMTORKCNH2PIK3CAATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021189036-A1 | TAF1 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2021-09-23 | — | — | WO | disclosed |