Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.41 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.40 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 6/20 | 0.32 |
| ▸ | MMP9 | P14780 | 5/20 | 0.32 |
| ▸ | MMP3 | P08254 | 3/20 | 0.32 |
| ▸ | MMP7 | P09237 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | BCR | P11274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92593 | 0.87 | PLK1 (0.51) | PIP4K2APIP4K2BPLK1PLK3PLK2 | |
| SCHEMBL10319396 | 0.87 | PLK1 (0.51) | PIP4K2APIP4K2BPLK1PLK3PLK2 | |
| SCHEMBL14952207 | 0.87 | PLK1 (0.43) | PIP4K2APIP4K2BPLK1PLK3PLK2 | |
| SCHEMBL30523195 | 0.87 | PLK1 (0.51) | PIP4K2APIP4K2BPLK1PLK3PLK2 | |
| SCHEMBL382821 | 0.87 | PLK1 (0.51) | PIP4K2APIP4K2BPLK1PLK3PLK2 | |
| SCHEMBL31098106 | 0.86 | PLK1 (0.44) | PIP4K2APIP4K2BPLK1PLK3PLK2 | |
| SCHEMBL1288242 | 0.85 | PLK1 (0.49) | PIP4K2APIP4K2BPLK1PLK3PLK2 | |
| SCHEMBL1288243 | 0.85 | PLK1 (0.49) | PIP4K2APIP4K2BPLK1PLK3PLK2 | |
| SCHEMBL5936768 | 0.82 | PLK1 (0.46) | PLK1PLK3PLK2BRD4KDM4E | |
| SCHEMBL10453154 | 0.81 | KDM4E (0.38) | PLK1PLK3PLK2BRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773096-B2 | Small-molecule PI5P4K alpha/beta inhibitors and methods of treatment using same | YALE UNIVERSITY (US) | 2023-10-03 | — | — | US | disclosed |
| US-20210292326-A1 | Small-Molecule PI5P4K alpha/beta Inhibitors and Methods of Treatment Using Same | UNIV YALE (US) | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773096-B2 | Small-molecule PI5P4K alpha/beta inhibitors and methods of treatment using same | PI4KB, TP53, PI4K2B | PIP4K2A 10/4885PIP4K2B 9/4885PLK1 140/4885 |
| US-20210292326-A1 | Small-Molecule PI5P4K alpha/beta Inhibitors and Methods of Treatment Using Same | PI4KB, TP53, PI4K2B | PIP4K2A 10/4885PIP4K2B 9/4885PLK1 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.