Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.51 |
| ▸ | PLK2 | Q9NYY3 | 15/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 13/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.34 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10319396 | 1.00 | PLK1 (0.51) | PLK1PLK2PLK3BRD4MAPK1 | |
| SCHEMBL382821 | 1.00 | PLK1 (0.51) | PLK1PLK2PLK3BRD4MAPK1 | |
| SCHEMBL92593 | 1.00 | PLK1 (0.51) | PLK1PLK2PLK3BRD4MAPK1 | |
| SCHEMBL1288242 | 0.98 | PLK1 (0.49) | PLK1PLK2PLK3BRD4MAPK1 | |
| SCHEMBL1288243 | 0.98 | PLK1 (0.49) | PLK1PLK2PLK3BRD4MAPK1 | |
| SCHEMBL5936768 | 0.95 | PLK1 (0.46) | PLK1PLK2PLK3BRD4MAPK1 | |
| SCHEMBL31098106 | 0.92 | PLK1 (0.44) | PLK1PLK2PLK3BRD4MAPK1 | |
| SCHEMBL5936900 | 0.90 | PLK1 (0.43) | PLK1PLK2PLK3BRD4MAPK1 | |
| SCHEMBL14952207 | 0.88 | PLK1 (0.43) | PLK1PLK2PLK3BRD4KDM4E | |
| SCHEMBL23849199 | 0.87 | PIP4K2A (0.41) | PLK1PLK2PLK3BRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118047779-B | Dihydropteridinone derivatives containing benzobisheteroaryl and use thereof | 沈阳药科大学 | 2025-02-11 | — | — | CN | disclosed |
| CN-119241548-A | Dihydropteridinone derivatives containing fused benzene rings and use thereof | 沈阳药科大学 | 2025-01-03 | — | — | CN | disclosed |
| CN-118047779-A | Dihydropteridinone derivatives containing benzobisheteroaryl and use thereof | 沈阳药科大学 | 2024-05-17 | — | — | CN | disclosed |
| CN-116396295-A | Synthesis method of PLK1 degradation agent based on PROTAC | 合肥工业大学 | 2023-07-07 | — | — | CN | disclosed |