Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11942151 | 1.00 | ALDH1A1 (0.60) | ALDH1A1KDM4ERECQLSMN1; SMN2ALOX15 | |
| SCHEMBL2104955 | 0.90 | ALDH1A1 (0.70) | ALDH1A1KDM4ERECQLSMN1; SMN2ALOX15 | |
| SCHEMBL14097292 | 0.82 | ALDH1A1 (0.61) | ALDH1A1KDM4ERECQLSMN1; SMN2HRH3 | |
| SCHEMBL363726 | 0.79 | TP53 (0.48) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL13713287 | 0.78 | ALDH1A1 (0.57) | ALDH1A1KDM4ERECQLSMN1; SMN2ALOX15 | |
| SCHEMBL16372109 | 0.78 | PHGDH (0.32) | ALDH1A1KDM4EALOX15HRH3 | |
| SCHEMBL23862929 | 0.78 | ALDH1A1 (0.57) | ALDH1A1KDM4ERECQLSMN1; SMN2ALOX15 | |
| Hydrochloric Acid SCHEMBL928103 | 0.77 | TP53 (0.47) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL19288712 | 0.77 | ALDH1A1 (0.56) | ALDH1A1KDM4ERECQLSMN1; SMN2ALOX15 | |
| SCHEMBL311214 | 0.77 | ALDH1A1 (0.56) | ALDH1A1KDM4ERECQLSMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12378250-B2 | Tricyclic compound as IRAK4 inhibitor | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2025-08-05 | — | — | US | disclosed |
| EP-3885348-B1 | NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR | KOREA RES INST CHEMICAL TECH (KR) | 2025-02-12 | — | — | EP | disclosed |
| CN-113227095-B | Novel tricyclic compounds as IRAK4 inhibitors | 韩国化学研究院 | 2024-07-05 | — | — | CN | disclosed |
| US-20220009933-A1 | NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2022-01-13 | — | — | US | disclosed |
| EP-3885348-A1 | NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR | Korea Research Institute of Chemical Technology (KR) | 2021-09-29 | — | — | EP | disclosed |
| EP-3885348-A1 | NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR | Korea Research Institute of Chemical Technology (KR) | 2021-09-29 | — | — | EP | disclosed |
| CN-113227095-A | Novel tricyclic compounds as IRAK4 inhibitors | 韩国化学研究院 | 2021-08-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12378250-B2 | Tricyclic compound as IRAK4 inhibitor | IRAK4, IRAK1, IRAK2 | ALDH1A1 2912/4885KDM4E 326/4885RECQL 3162/4885 |
| US-20220009933-A1 | NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR | IRAK4, IRAK1, IRAK2 | ALDH1A1 3048/4885KDM4E 363/4885RECQL 2789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.