⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12951568 | 1.00 | — | — | |
| SCHEMBL31419249 | 0.81 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL16968111 | 0.79 | — | — | |
| SCHEMBL17733305 | 0.79 | — | — | |
| SCHEMBL11512372 | 0.78 | — | — | |
| SCHEMBL4406953 | 0.74 | — | — | |
| SCHEMBL14521386 | 0.74 | — | — | |
| SCHEMBL2607905 | 0.74 | ALDH1A1 (0.32) | — | |
| SCHEMBL14401325 | 0.74 | — | — | |
| SCHEMBL2927509 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | claimed |
| EP-2215085-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-11 | — | — | EP | claimed |
| US-20090118305-A1 | PYRIDINE AND PYRAZINE DERIVATIVES - 083 | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | claimed |
| WO-2009053737-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | claimed |
| JP-11302224-A | — | — | None | — | — | JP | disclosed |
| JP-58183641-A | — | — | None | — | — | JP | disclosed |
| EP-3704090-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-05-27 | — | — | EP | disclosed |
| US-20250002445-A1 | Optimized process for manufacturing methyl methacrylate | LYGIN ALEXANDER (DE) | 2025-01-02 | — | — | US | disclosed |
| CN-118619830-A | Novel process for the preparation of methyl methacrylate via acetal type intermediate | 罗姆化学有限责任公司 | 2024-09-10 | — | — | CN | disclosed |
| US-20240018133-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2024-01-18 | — | — | US | disclosed |
| US-20240000792-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC | 2024-01-04 | — | — | US | disclosed |
| CN-113105475-B | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2022-09-09 | — | — | CN | disclosed |
| EP-0343583-B1 | A process for purifying methyl methacrylate | MITSUBISHI RAYON CO (JP) | 1994-12-14 | — | — | EP | disclosed |
| EP-0297445-B1 | METHOD FOR THE PRODUCTION OF METHACRYLIC ACID | BASF Aktiengesellschaft (DE) | 1992-02-12 | — | — | EP | disclosed |
| US-5087744-A | Gas phase oxidation of methacryloein or isobutyralde hyde over a molybdenum/phosphorous catalyst | BASF AKTIENGESELLSCHAFT (DE) | 1992-02-11 | — | — | US | disclosed |
| EP-0297445-A2 | Method for the production of methacrylic acid | BASF Aktiengesellschaft (DE) | 1989-01-04 | — | — | EP | disclosed |
| EP-0194620-A2 | Process for the preparation of methacrylic acid | BASF Aktiengesellschaft (DE) | 1986-09-17 | — | — | EP | disclosed |
| US-4499308-A | Catalytic reaction of acrolein and methacrolein with alcohols and glycols | THE STANDARD OIL COMPANY (US) | 1985-02-12 | — | — | US | disclosed |
| JP-S58183641-A | PURIFICATION OF METHYL (METH)ACRYLATE | ASAHI CHEM IND CO LTD | 1983-10-26 | — | — | JP | disclosed |
| US-4060677-A | Process for molecular weight lowering of vinyl halide polymers employing saturated carbon to carbon bonded aldehydes | HOOKER CHEMICALS & PLASTICS CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |